Developing a vaccine to protect against HIV infection
Consortium for HIV/AIDS Vaccine Development
This study is testing a new vaccine plan to help people build strong and lasting protection against HIV by encouraging their bodies to produce special antibodies that can fight off different strains of the virus.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10894260 on NIH RePORTER |
What this research studies
This research aims to create a sequential vaccine regimen that can induce long-lasting protective antibodies against HIV in humans. By targeting multiple sites on the HIV virus, the study seeks to ensure that over 90% of participants develop broadly neutralizing antibodies (bnAbs) that can effectively combat various strains of the virus. The approach involves designing specific immunogens that guide the immune response from initial antibody precursors to fully protective bnAbs. Additionally, the research will explore non-neutralizing antibodies that may enhance the overall immune response against HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at high risk for HIV infection who are willing to participate in clinical trials.
Not a fit: Patients who are already living with HIV or those who are not at risk for HIV infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a highly effective HIV vaccine that significantly reduces the risk of HIV infection.
How similar studies have performed: Previous research has shown promise in developing similar vaccine strategies, indicating potential for success in this novel approach.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Burton, Dennis R. — Scripps Research Institute, the
- Study coordinator: Burton, Dennis R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.