Developing a vaccine to prevent HIV infection using specific antigens
Vaccination with invariant MHC-II-linked accessory antigens for protection from HIV infection
This study is exploring a new type of vaccine that could help prevent HIV infection, and it's aimed at people who are interested in new ways to protect themselves from the virus, based on promising results from similar research.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-10906254 on NIH RePORTER |
What this research studies
This research investigates a new approach to creating a vaccine that aims to prevent HIV infection by utilizing conserved accessory antigens and a specialized MHC-II presentation system. The researchers have previously shown promising results in protecting against a similar virus, SIV, and are now focusing on refining their vaccine design to enhance its effectiveness. The study will involve testing this innovative vaccine in animal models to assess its ability to elicit a strong immune response and provide protection against HIV. Patients may benefit from this research if the vaccine proves successful in preventing HIV infection.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals at high risk of HIV exposure, including those in high-prevalence areas or with multiple risk factors.
Not a fit: Patients who are already HIV positive or those who do not have risk factors for HIV infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to an effective vaccine that significantly reduces the risk of HIV infection in at-risk populations.
How similar studies have performed: Previous research has shown success with similar vaccine approaches targeting conserved antigens, but this specific method is relatively novel and untested in humans.
Where this research is happening
New Orleans, United States
- Tulane University of Louisiana — New Orleans, United States (Active)
Researchers
- Principal investigator: Veazey, Ronald S. — Tulane University of Louisiana
- Study coordinator: Veazey, Ronald S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.