Developing a vaccine to prevent colon cancer
Official title: FURTHER DEVELOPMENT OF IPSC-BASED VACCINE FOR COLON CANCER PREVENTION
Funded at University of Tx Md Anderson Can Ctr · NIH-10893658 · Data updated 2026-11-12
This study is testing a new vaccine designed to help prevent colorectal cancer for people at high risk, like those with Lynch syndrome or familial adenomatous polyposis, by using special cells to boost the immune system and target early signs of cancer before they can develop.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | July 26, 2023 |
| Project end | July 25, 2026 |
| Funding year | 2023 |
| Award (this year) | $1,293,012 |
| NIH project number | 75N91019D00021-0-759102300001-1 |
| Project ID | NIH-10893658 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with hereditary conditions that increase their risk of colorectal cancer, such as Lynch syndrome or familial adenomatous polyposis.
✕Less likely to help
Patients without a family history of colorectal cancer or those not classified as high-risk may not benefit from this research.
What this research studies
This research focuses on creating a vaccine aimed at preventing colorectal cancer (CRC), particularly for individuals at high risk, such as those with Lynch syndrome or familial adenomatous polyposis. The approach involves using induced pluripotent stem cells (iPSCs) to develop immunopreventive vaccines that target specific proteins associated with cancer. By eliciting an immune response, the vaccine aims to eliminate precancerous cells before they develop into full-blown cancer. This proactive strategy complements existing screening methods and aims to provide a safer long-term prevention option.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of colorectal cancer in high-risk populations.
How similar studies have gone: While cancer vaccines have shown promise in various contexts, the specific approach of using iPSC-based vaccines for colorectal cancer prevention is relatively novel and has not been extensively tested.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Robinson, Prema — University of Tx Md Anderson Can Ctr
- Study coordinator: Robinson, Prema
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.