Developing a vaccine to improve flu protection in older adults.
Official title: TFH-TARGETING GENETIC ADJUVANTS TO PROMOTE DURABLE ANTI-INFLUENZA STEM ANTIBODIES IN OLDER ADULTS.
Funded at Tendel Therapies INC. · NIH-10933286 · Data updated 2026-11-12
This study is testing a new vaccine booster called BiTar-s3 to help older adults build a stronger defense against the flu by improving their immune response to different strains of the virus.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tendel Therapies INC. NIH-funded |
| Lab location | 1 site (Kensington, United States) |
| Project start | September 30, 2023 |
| Project end | September 29, 2025 |
| Funding year | 2023 |
| Award (this year) | $599,980 |
| NIH project number | 75N93023C00030-0-9999-1 |
| Project ID | NIH-10933286 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those who are at increased risk for influenza complications.
✕Less likely to help
Patients who are not older adults or those who have contraindications to vaccination may not benefit from this research.
What this research studies
This research focuses on creating a new vaccine adjuvant called BiTar-s3, which aims to enhance the immune response against influenza by targeting specific parts of the virus that are common across various strains. The project involves constructing immunogens that are combined with the BiTar-s3 adjuvant and testing their safety and effectiveness in animal models, including mice and aged rhesus macaques. By improving the ability to generate neutralizing antibodies against the flu, this research seeks to provide better protection for older adults who are at higher risk of severe influenza complications.
Why it matters
Potential benefit: If successful, this research could lead to a more effective flu vaccine that provides longer-lasting immunity for older adults.
How similar studies have gone: Other research has shown promise in using adjuvants to enhance vaccine responses, suggesting that this approach could be effective.
Where this research is happening
-
Tendel Therapies INC.
Kensington, United States Active
Researchers
- Principal investigator: Singleton, Kentner — Tendel Therapies INC.
- Study coordinator: Singleton, Kentner
Related research
Other NIH-funded projects on the same topics.
-
Creating vaccines for influenza and other infectious diseases
This study is all about creating new vaccines to help protect people from the flu and other infections, so patients can look forward to better options for staying healthy.
-
Creating vaccines for human trials against influenza and other infectious diseases
This study is working on creating new vaccines to help protect people from flu and other infectious diseases, including those that could be used in harmful situations, so that everyone can have safer and more effective options to stay healthy.
-
Understanding flu and COVID-19 vaccine responses in people and in the lab
Researchers at Stanford explore how flu and COVID-19 vaccines work in people and in lab tests to improve protection for adults.
-
Surveillance and preparedness for flu and other respiratory pathogens in Kenya
A US-based research grant aims to improve how Kenya detects and prepares for influenza and other respiratory diseases to protect people there and global health.
-
Enhanced Seasonal Influenza Vaccine Targeting Shared and Variable Viral Antigens
A new DNA-based influenza vaccine approach aims to provide both precise protection against circulating strains and broader defense against unexpected strains.
-
How the immune system responds to flu shots and flu infection
This project looks at how adults' immune systems react after flu shots or when they catch the flu to find why some people get better protection than others.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.