Developing a vaccine to help the immune system fight HIV
Native-like Envelope Trimer Therapeutic Vaccination for Induction of Broadly Neutralizing Antibodies to Facilitate HIV Functional Cure
['FUNDING_U01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-10789953
This study is testing a new vaccine designed to help people with chronic HIV infection strengthen their immune system so it can better fight the virus, with the hope of finding a way to manage or even cure HIV.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10789953 on ClinicalTrials.gov |
What this research studies
This research focuses on creating a therapeutic vaccine that aims to stimulate the immune system to produce broadly neutralizing antibodies (bnAbs) against HIV. By using native-like HIV envelope trimers, the study seeks to enhance the immune response in individuals with chronic HIV infection, potentially leading to a functional cure. The approach involves testing the vaccine's ability to boost existing immune responses in patients who have been on antiretroviral therapy. If successful, this could provide a new avenue for HIV treatment and prevention.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with chronic HIV infection who are currently receiving antiretroviral therapy.
Not a fit: Patients who are not infected with HIV or those who have acute HIV infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a significant advancement in the treatment and prevention of HIV, potentially allowing patients to achieve a functional cure.
How similar studies have performed: Previous research has shown promise in using broadly neutralizing antibodies for HIV treatment, indicating that this approach has potential based on earlier successes.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RIDDLER, SHARON — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: RIDDLER, SHARON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.