Developing a vaccine to create protective immune cells against Salmonella infections
Official title: Vaccine induction of Salmonella-specific Th1 memory cells
Funded at University of California at Davis · NIH-11031610 · Data updated 2026-11-12
This study is looking at how a new vaccine can help your immune system fight off Salmonella infections by boosting special immune cells, and it will also test a new way to deliver the vaccine that might make it work even better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | September 26, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $225,839 |
| NIH project number | 1R21AI187632-01 |
| Project ID | NIH-11031610 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under the age of 11 who are at risk for Salmonella infections.
✕Less likely to help
Patients who are older than 11 years or those who have already been vaccinated against Salmonella may not benefit from this research.
What this research studies
This research focuses on understanding how a vaccine can effectively induce specific immune cells known as Th1 memory cells to protect against Salmonella infections. The study will investigate the role of IL-18R expression in these immune cells and their location in the liver, which may enhance their protective capabilities. Additionally, the researchers will explore the use of an innovative mRNA nanoparticle delivery system to improve the vaccine's effectiveness in generating these protective immune responses.
Why it matters
Potential benefit: If successful, this research could lead to a more effective vaccine that provides better protection against Salmonella infections in children.
How similar studies have gone: Previous research has shown promising results in using mRNA technology for vaccine development, indicating potential success for this approach.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Mcsorley, Stephen J — University of California at Davis
- Study coordinator: Mcsorley, Stephen J
Related research
Other NIH-funded projects on the same topics.
-
UC Davis IGA Innovation Center
A research center at UC Davis will study gene-edited livestock to improve animal health, safety, and policy through sharing genetic data and findings about genome edits in cattle, pigs, sheep, and goats.
-
Administrative Core of an equitable breast cancer screening program
A national program headed from UC Davis is coordinating several research efforts to improve how breast cancer screening is done in community settings.
-
The role of novelty and surprise in learning for people with Alzheimer’s disease
A study explores how surprising events affect memory and learning in people related to Alzheimer’s disease, using everyday tasks to see how the brain remembers new information.
-
Understanding how distraction affects students and how to measure it better
This grant studies why distracted students, including those with ADHD, struggle in real-life learning and tests a clearer way to measure distraction in everyday settings.
-
California Partnership for Personalized Nutrition
A California clinical center is testing personalized dietary approaches to improve blood sugar and health for adults with diabetes by using big data and AI to tailor meals.
-
Advancing gastric cancer care for Latinos through patient-derived tumor models
Aimed at Latinos with gastric cancer, this project uses patient-derived tumor models to study how cancer biology and treatments work in real tumors.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.