Developing a vaccine to create protective immune cells against Salmonella infections
Vaccine induction of Salmonella-specific Th1 memory cells
This study is looking at how a new vaccine can help your immune system fight off Salmonella infections by boosting special immune cells, and it will also test a new way to deliver the vaccine that might make it work even better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11031610 on NIH RePORTER |
What this research studies
This research focuses on understanding how a vaccine can effectively induce specific immune cells known as Th1 memory cells to protect against Salmonella infections. The study will investigate the role of IL-18R expression in these immune cells and their location in the liver, which may enhance their protective capabilities. Additionally, the researchers will explore the use of an innovative mRNA nanoparticle delivery system to improve the vaccine's effectiveness in generating these protective immune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under the age of 11 who are at risk for Salmonella infections.
Not a fit: Patients who are older than 11 years or those who have already been vaccinated against Salmonella may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a more effective vaccine that provides better protection against Salmonella infections in children.
How similar studies have performed: Previous research has shown promising results in using mRNA technology for vaccine development, indicating potential success for this approach.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Mcsorley, Stephen J — University of California at Davis
- Study coordinator: Mcsorley, Stephen J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.