Developing a vaccine to block malaria transmission
Identification & Evaluation of Novel Malaria Anti-Gametocyte Transmission Blocking Vaccine Candidate Antigens
['FUNDING_R01'] · BROWN UNIVERSITY · NIH-10665613
This study is looking for new ways to help create a malaria vaccine by examining blood samples from teenagers and adults in Kenya to see how their immune responses can stop the spread of malaria from people to mosquitoes, which could help reduce malaria infections overall.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BROWN UNIVERSITY (nih funded) |
| Locations | 1 site (PROVIDENCE, UNITED STATES) |
| Trial ID | NIH-10665613 on ClinicalTrials.gov |
What this research studies
This research aims to identify new candidate antigens for a vaccine that can block the transmission of malaria from humans to mosquitoes. By focusing on reducing the levels of gametocytes, the form of malaria that can infect mosquitoes, the study seeks to lower the incidence of malaria infections in humans. The researchers will analyze blood samples from Kenyan adolescents and adults to understand how antibodies to these gametocytes can help in reducing transmission. This approach could lead to a significant breakthrough in malaria control efforts.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living in malaria-endemic regions, particularly adolescents and adults who may have been exposed to malaria.
Not a fit: Patients who do not reside in malaria-endemic areas or those who have never been exposed to malaria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a vaccine that significantly reduces malaria transmission, ultimately lowering the incidence of malaria infections in the population.
How similar studies have performed: Previous research has shown promise in developing vaccines targeting malaria transmission, indicating that this approach has potential based on earlier successes.
Where this research is happening
PROVIDENCE, UNITED STATES
- BROWN UNIVERSITY — PROVIDENCE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NIXON, CHRISTIAN PARCHER — BROWN UNIVERSITY
- Study coordinator: NIXON, CHRISTIAN PARCHER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.