Developing a vaccine that targets specific areas of the HIV virus
Vaccine targeting HIV sites of vulnerability
This study is testing a new vaccine designed to help your body fight HIV by targeting a specific part of the virus, and it’s looking for people to join the trials to see how well it works and if it’s safe.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | James J Peters VA Medical Center NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10948080 on NIH RePORTER |
What this research studies
This research focuses on creating a vaccine that targets the V1V2 region of the HIV virus to enhance the immune response against it. By using a novel recombinant subunit immunogen, the study aims to induce antibodies that are specifically directed towards this vulnerable site on the virus, potentially improving the effectiveness of HIV prevention. The approach includes testing the vaccine's ability to generate a strong and durable immune response, as well as its capacity to activate various immune functions that can help eliminate the virus. Patients may be involved in trials to assess the safety and efficacy of this new vaccine candidate.
Who could benefit from this research
Good fit: Ideal candidates for participation would include individuals at high risk for HIV infection who are seeking preventive options.
Not a fit: Patients who are already HIV positive or those who do not have a risk of HIV exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a more effective HIV vaccine, significantly reducing the risk of HIV infection.
How similar studies have performed: Previous vaccine trials, such as the Thai RV144 trial, have shown some success in eliciting immune responses against HIV, indicating that this targeted approach may hold promise.
Where this research is happening
Bronx, United States
- James J Peters VA Medical Center — Bronx, United States (Active)
Researchers
- Principal investigator: Hioe, Catarina E — James J Peters VA Medical Center
- Study coordinator: Hioe, Catarina E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.