Developing a vaccine targeting common tumor antigens
Vaccination against antigens induced by TAP downregulation in concurrent and future tumors
['FUNDING_R01'] · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · NIH-10891472
This study is testing a new vaccine that helps the immune system recognize and fight cancer cells by targeting specific changes in those cells, and it aims to help people with different types of tumors, especially those that keep coming back.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MIAMI SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (CORAL GABLES, UNITED STATES) |
| Trial ID | NIH-10891472 on ClinicalTrials.gov |
What this research studies
This research focuses on creating a vaccine that targets specific antigens induced in tumor cells when key components of the antigen processing pathway are downregulated. By using a method that genetically alters tumor cells, the vaccine aims to stimulate the immune system to recognize and attack these cancer cells. This approach is designed to be broadly applicable, potentially benefiting patients with various types of tumors, including those that are recurrent or concurrent. The research will evaluate the effectiveness of this vaccination strategy in stimulating T cell responses without causing significant toxicity.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with concurrent, recurrent, or future tumors that may express the targeted antigens.
Not a fit: Patients whose tumors do not express the specific antigens targeted by this vaccination strategy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new, effective vaccination method for patients with different types of tumors, enhancing their immune response against cancer.
How similar studies have performed: Previous studies have shown promising results with similar vaccination strategies targeting induced antigens, indicating potential for success in this approach.
Where this research is happening
CORAL GABLES, UNITED STATES
- UNIVERSITY OF MIAMI SCHOOL OF MEDICINE — CORAL GABLES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GILBOA, ELI — UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- Study coordinator: GILBOA, ELI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.