Developing a vaccine for the tickborne SFTS virus
Tickborne SFTS Virus Vaccine Development
This study is testing four different vaccine options to see if they can help protect older people from Severe Fever with Thrombocytopenia Syndrome (SFTS), a serious illness caused by a tick-borne virus, since there are no vaccines available for it yet.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10893044 on NIH RePORTER |
What this research studies
This research focuses on creating a vaccine for Severe Fever with Thrombocytopenia Syndrome (SFTS), a serious tick-borne disease caused by the SFTS virus. The project aims to evaluate the effectiveness of four different vaccine candidates in protecting against SFTSV infection, particularly in older populations who are at higher risk. Researchers will use an age-dependent ferret model to assess how well these vaccines stimulate the immune response and provide protection. The study is crucial as there are currently no effective vaccines available for this emerging infectious disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals, particularly older adults, who are at risk of SFTS due to tick exposure.
Not a fit: Patients who are not at risk of tick exposure or who are younger than 50 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of a vaccine that significantly reduces the incidence and mortality of SFTS in affected populations.
How similar studies have performed: While there has been significant research into vaccines for other tick-borne diseases, this specific approach for SFTS is novel and untested.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Jung, Jae U — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Jung, Jae U
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.