Developing a vaccine for HIV using advanced antibody analysis techniques
Official title: Scientific Core: Structural Proteomics
Funded at Scripps Research Institute, the · NIH-11076794 · Data updated 2026-11-12
This study is working on creating a better vaccine for HIV by looking closely at how our immune system's antibodies react to the virus, using some really cool technology, to help design stronger treatments for people living with HIV.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | June 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $184,000 |
| NIH project number | 5P01AI177683-03 |
| Project ID | NIH-11076794 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at high risk for HIV infection or those living with HIV who may benefit from improved vaccine strategies.
✕Less likely to help
Patients who are not at risk for HIV or those who are already receiving effective treatment may not benefit from this research.
What this research studies
This research focuses on designing a vaccine for HIV by utilizing innovative techniques to analyze how antibodies respond to the virus. It employs advanced methods like single-cell RNA sequencing and electron microscopy to gain detailed insights into immune responses. By integrating these technologies, the research aims to identify specific antibody interactions with the virus, which could lead to more effective vaccine designs. The goal is to streamline the process of creating monoclonal antibodies that can target HIV effectively.
Why it matters
Potential benefit: If successful, this research could lead to the development of a more effective HIV vaccine, improving prevention strategies for patients at risk of infection.
How similar studies have gone: Previous research has shown promising results in vaccine development using similar advanced immunological techniques, indicating a potential for success in this approach.
Where this research is happening
-
Scripps Research Institute, the
La Jolla, United States Active
Researchers
- Principal investigator: Ward, Andrew Barrett — Scripps Research Institute, the
- Study coordinator: Ward, Andrew Barrett
Related research
Other NIH-funded projects on the same topics.
-
The Participant Center helps people join and stay in a nationwide health study
A nationwide program to support people in joining, contributing biosamples, and staying connected to a large health study in the United States.
-
Data Sharing and Bioinformatics Core for Viral Systems Biology
A center-led effort to manage, share, and interpret large viral systems biology data using open tools and a community-friendly portal.
-
Germline-targeted HIV vaccines using membrane liposome tech to trigger bnAbs
A new HIV vaccine approach aims to spark broadly neutralizing antibodies by showing MPER on membranes, tested in models and early studies to guide future human trials.
-
Antivirals for hemorrhagic fever viruses like LASV, SFTSV, and EBOV
A multi-institutional effort to find and validate antiviral compounds that block key viral proteins from LASV, SFTSV, and EBOV to help people at risk from serious hemorrhagic fevers.
-
Developing new antivirals for flaviviruses
A research team is working to create oral antiviral drugs targeting flaviviruses to treat infections that affect millions of people.
-
CoV inhibitors targeting non-enzymatic SARS-CoV-2 components
A multicenter research effort seeks antiviral ideas that block SARS-CoV-2 parts that don’t work through traditional enzymes, aiming to help people affected by COVID-19.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.