Developing a vaccine for chronic hepatitis C using non-human primates
Core-002 - Non-Human Primate Core
This study is working on a new vaccine to help people with chronic hepatitis C by testing it in monkeys to see how well it boosts the immune system's response to the virus.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11015062 on NIH RePORTER |
What this research studies
This research focuses on creating a vaccine for chronic hepatitis C virus (HCV) infection, which affects millions globally. It utilizes advanced techniques to design and present HCV antigens on nanoparticles, aiming to enhance the immune response. The study involves testing these vaccine candidates in rhesus macaques, a non-human primate model, to gather valuable data on how the immune system reacts to the vaccine. Blood and tissue samples will be collected for detailed analysis of the immune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of chronic hepatitis C infection or those who are chronically infected and seeking new treatment options.
Not a fit: Patients who are not at risk for hepatitis C or those who have already been cured of the infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to an effective vaccine for chronic hepatitis C, potentially saving lives and improving health outcomes for millions.
How similar studies have performed: While there have been challenges in developing HCV vaccines, this approach utilizing non-human primates and advanced antigen presentation techniques is innovative and may offer new insights.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Chen, Christopher Yeh — Scripps Research Institute, the
- Study coordinator: Chen, Christopher Yeh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.