Developing a urine test for diagnosing tuberculosis in children
Host Proteomic Biosignatures for a Urine-based Diagnosis of Pulmonary Tuberculosis in Children
This study is working on a simple urine test to help doctors find out if children have tuberculosis (TB), making it easier to diagnose without needing difficult sputum samples.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10923850 on NIH RePORTER |
What this research studies
This research focuses on creating a non-invasive urine-based test to diagnose pulmonary tuberculosis (TB) in children, addressing the challenges of obtaining sputum samples. The study will analyze urine samples from children suspected of having TB to identify specific proteins that can serve as biomarkers for the disease. By using advanced mass spectrometry techniques, researchers aim to discover unique protein signatures that indicate the presence of TB, which could lead to more accurate and accessible diagnostic methods for young patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who are symptomatic and being evaluated for pulmonary tuberculosis.
Not a fit: Patients who do not exhibit symptoms of tuberculosis or are older than 21 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a reliable and easy-to-use urine test for diagnosing tuberculosis in children, potentially saving lives through earlier detection and treatment.
How similar studies have performed: Other research has shown promise in using biomarker-based approaches for diagnosing tuberculosis, indicating that this method could be a viable advancement in TB diagnostics.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Jaganath, Devan — University of California, San Francisco
- Study coordinator: Jaganath, Devan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.