Developing a treatment to reduce gastrointestinal damage from radiation exposure
Development of YK-4-250, a radiation mitigator of GI-ARS
This study is looking at a new treatment called YK-4-250 that might help protect your stomach and intestines from damage caused by radiation, which can happen in certain situations, and they want to see if it can help people recover better after exposure.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Old Dominion University NIH-funded |
| Lab location | 1 site (Norfolk, United States) |
| Project ID | NIH-11017255 on NIH RePORTER |
What this research studies
This research focuses on finding a way to protect the gastrointestinal system from damage caused by ionizing radiation, which can lead to Acute Radiation Syndrome (GI-ARS). The team is investigating a new compound called YK-4-250 that targets specific receptors in the body to reduce the harmful effects of radiation. By administering this compound after radiation exposure, they aim to improve recovery and survival rates. The study will assess the safety and effectiveness of this treatment in preclinical models before considering human applications.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals who are at risk of radiation exposure, such as those in military or emergency response roles.
Not a fit: Patients who have not been exposed to radiation or those with pre-existing gastrointestinal conditions unrelated to radiation exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new treatment option to significantly improve survival and recovery for individuals exposed to harmful radiation.
How similar studies have performed: While the approach of using targeted compounds to mitigate radiation effects is being explored, this specific treatment is novel and has not been widely tested in humans.
Where this research is happening
Norfolk, United States
- Old Dominion University — Norfolk, United States (Active)
Researchers
- Principal investigator: Brown, Milton L. — Old Dominion University
- Study coordinator: Brown, Milton L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.