Developing a test for early detection of ovarian cancer
A multidisciplinary BCC for ovarian cancer early detection: translating discoveries to clinical use with a by-design approach
['FUNDING_OTHER'] · JOHNS HOPKINS UNIVERSITY · NIH-10906352
This study is looking for ways to find early signs of high-grade serous ovarian cancer in women at higher risk, especially those with BRCA1/2 gene changes, by using blood samples to help develop a new test that could catch the cancer sooner.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10906352 on ClinicalTrials.gov |
What this research studies
This research focuses on identifying and validating biomarkers for high-grade serous ovarian carcinoma (HGSOC), the most common type of ovarian cancer. The team aims to create an in vitro diagnostic multivariate index assay (IVDMIA) that can detect early stages of HGSOC in high-risk women, particularly those with BRCA1/2 mutations. By utilizing advanced data generation technologies and bioinformatics, the project seeks to improve early detection methods tailored to the biology of ovarian cancer. Patients may contribute by providing blood samples and participating in the validation of these biomarkers.
Who could benefit from this research
Good fit: Ideal candidates for this research are high-risk women, particularly those who are BRCA1/2 mutation carriers.
Not a fit: Patients who do not have a family history of ovarian cancer or are not BRCA1/2 carriers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection of ovarian cancer, improving treatment outcomes for high-risk women.
How similar studies have performed: Previous research has shown promise in using biomarkers for cancer detection, indicating potential success for this approach.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHANG, ZHEN — JOHNS HOPKINS UNIVERSITY
- Study coordinator: ZHANG, ZHEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.