Developing a skin vaccine to create long-lasting immune cells for lung protection
Skin vaccination and generation of protective lung-tropic memory T cells
This study is exploring a new way to give vaccines through the skin to help your body build stronger and longer-lasting defenses against lung infections, which could lead to better protection against respiratory viruses for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11002019 on NIH RePORTER |
What this research studies
This research focuses on creating a skin vaccination method that generates protective immune cells specifically targeting the lungs. It aims to enhance the durability of lung-resident memory T cells, which are crucial for long-term immunity against respiratory viruses. By studying a unique population of CD8 T cells that can quickly respond to lung infections, the research seeks to improve vaccine effectiveness and provide rapid protection. Patients may benefit from a more effective vaccine that offers longer-lasting immunity against respiratory viral infections.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at high risk for respiratory infections, such as those with chronic lung conditions or weakened immune systems.
Not a fit: Patients who are not at risk for respiratory infections or those with existing immunity may not receive significant benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to vaccines that provide long-lasting protection against respiratory viruses, reducing the risk of severe illness.
How similar studies have performed: Previous research has shown promise in developing vaccines that enhance T cell immunity, suggesting potential for success in this novel approach.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Kupper, Thomas S. — Brigham and Women's Hospital
- Study coordinator: Kupper, Thomas S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.