Developing a platform to test drugs for fatty liver disease based on genetic variants
Implementing A QSP Platform to Predict and Test Drugs for Metabolic Associated Fatty Liver Disease Genetic Variants in an iPSC-cell Based Human Biomimetic Liver Microphysiology System
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11019799
This study is looking at fatty liver disease and aims to create a mini-liver model to help find new treatments, so people with this condition can learn more about how their genes affect their health and potentially benefit from new targeted therapies.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11019799 on ClinicalTrials.gov |
What this research studies
This research focuses on metabolic dysfunction associated fatty liver disease (MAFLD), a significant public health issue with no approved treatments. The team is creating a human liver microphysiology system that mimics the liver's environment, allowing for the study of various genetic variants linked to MAFLD. By using advanced computational methods and genome-edited stem cells, the researchers aim to identify and test potential drugs that could effectively treat this condition. Patients may benefit from insights into how specific genetic factors influence their disease and the development of targeted therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with metabolic dysfunction associated fatty liver disease, particularly those with known genetic variants linked to the condition.
Not a fit: Patients without metabolic dysfunction associated fatty liver disease or those with unrelated liver conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new or repurposed drugs that effectively treat fatty liver disease based on individual genetic profiles.
How similar studies have performed: Other research has shown promise in using similar biomimetic systems and computational approaches to develop targeted therapies for complex diseases.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MIEDEL, MARK T. — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: MIEDEL, MARK T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.