Developing a peptide to help drugs cross the blood-brain barrier
Official title: Rational design and testing of blood-brain-barrier shuttle peptide
Funded at Northeast Ohio Medical University · NIH-11003722 · Data updated 2026-11-12
This study is working on a special helper that can make it easier for important medications to reach the brain, which is often tough to do for people with brain-related conditions, so they can get better treatment with fewer side effects.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeast Ohio Medical University NIH-funded |
| Lab location | 1 site (Rootstown, United States) |
| Project start | December 22, 2023 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $78,000 |
| NIH project number | 5R03NS135326-02 |
| Project ID | NIH-11003722 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with neurological disorders that require effective drug therapies.
✕Less likely to help
Patients with conditions that do not involve the central nervous system may not benefit from this research.
What this research studies
This research focuses on creating a specialized peptide that can facilitate the transport of therapeutic drugs across the blood-brain barrier (BBB), which is a significant challenge in treating central nervous system conditions. The approach involves targeting specific receptors on the BBB to enhance drug delivery while minimizing side effects. By improving the ability of drugs to penetrate the BBB, this research aims to increase the chances of successful treatment options for patients with neurological disorders. The methodology includes designing and testing these peptides to ensure they effectively bind to the BBB receptors.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for neurological conditions by improving drug delivery to the brain.
How similar studies have gone: Previous research has shown promise in using receptor-targeted approaches to enhance drug delivery across the BBB, indicating potential for success in this area.
Where this research is happening
-
Northeast Ohio Medical University
Rootstown, United States Active
Researchers
- Principal investigator: Shin, Woo Shik — Northeast Ohio Medical University
- Study coordinator: Shin, Woo Shik
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.