Developing a non-hormonal contraceptive pill for men
Official title: IND-enabling studies to develop triptonide into the first nonhormonal male pill
Funded at Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center · NIH-11017008 · Data updated 2026-11-12
This study is looking at a new male birth control pill called triptonide, which has shown promise in early tests for being safe and effective, and it aims to gather important information to help get it approved for use.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center NIH-funded |
| Lab location | 1 site (Torrance, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $353,443 |
| NIH project number | 5R61HD114186-02 |
| Project ID | NIH-11017008 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would be men seeking non-hormonal contraceptive methods.
✕Less likely to help
Patients who are not male or those who are not interested in contraceptive options may not receive any benefit from this research.
What this research studies
This research focuses on triptonide (TN), a promising non-hormonal male contraceptive agent that has shown excellent potency and oral bioavailability without toxic effects in preliminary studies. The project aims to conduct essential studies to gather data required for FDA approval, including toxicity and safety pharmacology assessments in animal models. By utilizing advanced techniques such as deep learning and RNA sequencing, the research will provide insights into the drug's safety profile and potential effects. This comprehensive approach is designed to pave the way for TN to become a viable contraceptive option for men.
Why it matters
Potential benefit: If successful, this research could lead to the first non-hormonal contraceptive pill for men, providing more family planning options.
How similar studies have gone: While the concept of a non-hormonal male contraceptive is novel, previous research has shown promise in similar approaches, indicating potential for success.
Where this research is happening
-
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Torrance, United States Active
Researchers
- Principal investigator: Yan, Wei — Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Study coordinator: Yan, Wei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.