Developing a new vaccine to prevent pneumonia in older adults
Liposomal Encapsulation Vaccine Design for Pneumococcal Disease in Aged Subjects
This study is testing a new type of vaccine designed to better protect older adults, especially those 65 and up, from pneumonia caused by pneumococcal bacteria, by combining different ingredients to boost their immune response.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project ID | NIH-11083108 on NIH RePORTER |
What this research studies
This research focuses on creating a novel vaccine formulation called Liposomal Encapsulation of Polysaccharides (LEPS) to enhance protection against pneumococcal disease, particularly in individuals aged 65 and older. The study aims to improve immune responses by combining polysaccharide and protein antigens, which may provide broader protection against various strains of the bacteria. By testing this vaccine in aged mice, the researchers hope to demonstrate its effectiveness compared to existing vaccines, ultimately aiming to reduce the incidence of pneumonia and related complications in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are at risk for pneumococcal disease.
Not a fit: Patients younger than 65 years old or those who do not have risk factors for pneumococcal disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the risk of pneumonia and improve health outcomes for older adults.
How similar studies have performed: Previous research has shown promise with similar vaccine approaches, indicating potential for success in this novel formulation.
Where this research is happening
Amherst, United States
- State University of New York at Buffalo — Amherst, United States (Active)
Researchers
- Principal investigator: Pfeifer, Blaine a. — State University of New York at Buffalo
- Study coordinator: Pfeifer, Blaine a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.