Developing a new vaccine to combat HIV-1/AIDS
Structure and immunogenicity of novel trimeric HIV-1 Env immunogens
['FUNDING_R01'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-10677620
This study is working on a new HIV vaccine that aims to help your body make better antibodies by focusing on a specific part of the virus, making it easier for your immune system to fight off HIV.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10677620 on ClinicalTrials.gov |
What this research studies
This research focuses on creating a novel vaccine for HIV-1/AIDS by stabilizing the structure of the virus's envelope protein, known as Env. The approach involves using a divide-and-conquer strategy to develop immunogens that target specific parts of the Env trimer, which helps to direct the immune response more effectively. By designing trimeric immunogens based on the V1V2 domain of the Env, the researchers aim to enhance the production of antibodies that can provide protection against HIV-1. This innovative method seeks to avoid the distractions of unwanted antibody responses that have hindered previous vaccine efforts.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at high risk for HIV-1 infection or those living with HIV who are seeking new treatment options.
Not a fit: Patients who are not at risk for HIV-1 or those who are already effectively managing their HIV with existing treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a more effective vaccine against HIV-1, potentially reducing the incidence of AIDS.
How similar studies have performed: Previous research has shown promise in developing vaccines targeting specific domains of the HIV envelope, but this approach is considered innovative and may offer new insights.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KONG, XIANGPENG — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: KONG, XIANGPENG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immuno-Deficiency Syndrome, Acquired Immunologic Deficiency Syndrome, Acquired Immunodeficiency Syndrome