Developing a new vaccine for C. difficile infections
Oklahoma C. difficile U19 Challenge Core
['FUNDING_OTHER'] · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · NIH-10892822
This study is looking at how to make a better vaccine for C. difficile by figuring out why some vaccines don't work as well as they should, using tests on mice and hamsters to find ways to improve the vaccine and help prevent infections in people.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR (nih funded) |
| Locations | 1 site (OKLAHOMA CITY, UNITED STATES) |
| Trial ID | NIH-10892822 on ClinicalTrials.gov |
What this research studies
This research focuses on advancing a second-generation vaccine for C. difficile by investigating the mechanisms that limit the effectiveness of vaccine-induced immune responses. Using animal models, including mice and hamsters, the project will conduct challenge experiments to test the efficacy of the vaccine. The research aims to standardize these experiments to ensure reliable results and improve the overall understanding of how to enhance vaccine responses. By optimizing these models, the research seeks to provide valuable insights that could lead to better prevention strategies against C. difficile infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at high risk for C. difficile infections, such as those with a history of antibiotic use or gastrointestinal disorders.
Not a fit: Patients who are not at risk for C. difficile infections or those who have already been vaccinated may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a more effective vaccine that significantly reduces the incidence of C. difficile infections in patients.
How similar studies have performed: Previous research has shown promise in developing vaccines for C. difficile, but this approach aims to refine and enhance existing methodologies, making it a novel effort in the field.
Where this research is happening
OKLAHOMA CITY, UNITED STATES
- UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR — OKLAHOMA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BALLARD, JIMMY D. — UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
- Study coordinator: BALLARD, JIMMY D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.