Developing a new vaccine approach for HIV using liposomes and mRNA.
Official title: Feasibility for Development of a Liposome/LNP Displaying an HIV Env Trimer Protein and Containing/Incorporating an mRNA
Funded at Duke University · NIH-11181783 · Data updated 2026-11-12
This study is working on a new vaccine that uses tiny bubbles called liposomes and mRNA to help your body fight HIV better, and it aims to improve prevention and treatment options for people living with or at risk of HIV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | August 31, 2024 |
| Project end | August 27, 2028 |
| Funding year | 2024 |
| Award (this year) | $2,456,817 |
| NIH project number | 75N93022D00003-0-759302400001-1 |
| Project ID | NIH-11181783 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals at risk for HIV or those interested in participating in future vaccine trials.
✕Less likely to help
Patients who are already living with HIV and are not interested in vaccine prevention strategies may not benefit from this research.
What this research studies
This research focuses on creating a novel vaccine that utilizes liposomes and mRNA to present an HIV Env trimer protein. The approach aims to enhance the immune response against HIV by effectively delivering the vaccine components. The project will involve preclinical testing and the development of manufacturing processes to ensure the vaccine can be produced at scale. Patients may benefit from advancements in HIV prevention and treatment as this research progresses through various stages of development.
Why it matters
Potential benefit: If successful, this research could lead to a more effective vaccine for HIV, improving prevention and treatment options for patients.
How similar studies have gone: Other research has shown promise in using mRNA technology for vaccine development, indicating potential success for this approach.
Where this research is happening
-
Duke University
Durham, United States Active
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.