Developing a new type of vascular graft to improve heart surgery outcomes
Preclinical Assessment of a Compliance Matched Biopolymer Vascular Graft
This study is testing a new kind of heart bypass graft that is designed to work better with your blood vessels, helping to reduce the chances of it failing after surgery and promoting faster healing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11222523 on NIH RePORTER |
What this research studies
This research focuses on creating a new type of vascular graft designed to improve the success rates of coronary artery bypass graft (CABG) surgeries. It aims to address the issue of graft failure, which can occur due to mismatched compliance between the graft and the patient's blood vessels. By engineering a biodegradable graft that maintains proper compliance and supports healthy cell growth, the researchers hope to enhance the healing process and reduce complications. The approach involves using advanced tissue engineering techniques and computational simulations to optimize the graft's properties before implantation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals undergoing coronary artery bypass graft surgery, particularly those at risk of graft failure.
Not a fit: Patients who are not candidates for CABG surgery or those with other severe comorbidities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and durable vascular grafts, significantly improving recovery and outcomes for patients undergoing heart surgery.
How similar studies have performed: Previous research in tissue engineering has shown promise in developing vascular grafts, but this specific approach to compliance matching is relatively novel.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Vande Geest, Jonathan Pieter — University of Pittsburgh at Pittsburgh
- Study coordinator: Vande Geest, Jonathan Pieter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.