Developing a new type of blood thinner that reduces clotting without causing bleeding.
Lead identification and pre-clinical studies on allosteric inhibitors of coagulation factor XIa
['FUNDING_OTHER'] · VIRGINIA COMMONWEALTH UNIVERSITY · NIH-11009811
This study is working on a new blood thinner that aims to prevent clots without causing the heavy bleeding risks that come with current options, and it's for anyone who needs safer treatments for managing their blood clotting issues.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VIRGINIA COMMONWEALTH UNIVERSITY (nih funded) |
| Locations | 1 site (RICHMOND, UNITED STATES) |
| Trial ID | NIH-11009811 on ClinicalTrials.gov |
What this research studies
This research focuses on creating a novel anticoagulant that can effectively prevent blood clots without the significant bleeding risks associated with current treatments. The approach involves designing an allosteric inhibitor that selectively targets a specific site on the coagulation factor XIa, which plays a crucial role in blood clotting. The researchers have already developed a promising compound, sulfated D-chiro-inositol (SCI), which has shown effectiveness in animal models without increasing bleeding. The goal is to further refine this compound to improve its pharmacokinetics and therapeutic potential.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from thrombotic conditions such as heart attacks, strokes, or certain cancers.
Not a fit: Patients who do not have thrombotic diseases or those who are not at risk for blood clots may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a safer anticoagulant option for patients at risk of thrombotic diseases.
How similar studies have performed: Previous research has shown promise in developing similar anticoagulants, but this specific approach is innovative and has not been extensively tested.
Where this research is happening
RICHMOND, UNITED STATES
- VIRGINIA COMMONWEALTH UNIVERSITY — RICHMOND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DESAI, UMESH RAMANLAL — VIRGINIA COMMONWEALTH UNIVERSITY
- Study coordinator: DESAI, UMESH RAMANLAL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers