Developing a new treatment to prevent infections and gastrointestinal issues from chemotherapy
Official title: Preventing chemotherapy-related toxicities and infections with a novel phosphorylated triblock copolymer
Funded at Covira Surgical · NIH-10821023 · Data updated 2026-11-12
This study is testing a new treatment designed to help protect your gut health during chemotherapy, making it safer and more effective by reducing the risk of infections and other problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Covira Surgical NIH-funded |
| Lab location | 1 site (North Chicago, United States) |
| Project start | September 18, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $400,000 |
| NIH project number | 1R41CA287593-01 |
| Project ID | NIH-10821023 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer patients who are undergoing chemotherapy and are at risk for gastrointestinal toxicities and infections.
✕Less likely to help
Patients who are not undergoing chemotherapy or those with pre-existing gastrointestinal conditions may not benefit from this research.
What this research studies
This research focuses on creating a novel agent that aims to prevent gastrointestinal toxicities and infections that often occur in patients undergoing chemotherapy. Chemotherapy can disrupt the gut microbiome and lead to serious complications, including increased susceptibility to infections. The approach involves preserving the beneficial aspects of the gut microbiome while mitigating its harmful effects, thus improving patient outcomes. By addressing these issues, the research seeks to enhance the safety and effectiveness of chemotherapy treatments.
Why it matters
Potential benefit: If successful, this research could significantly reduce the risk of infections and gastrointestinal complications for chemotherapy patients.
How similar studies have gone: While the approach is innovative, there is a growing body of research exploring the preservation of gut microbiome health during chemotherapy, indicating potential for success.
Where this research is happening
-
Covira Surgical
North Chicago, United States Active
Researchers
- Principal investigator: Hennessey, Patrick — Covira Surgical
- Study coordinator: Hennessey, Patrick
Related research
Other NIH-funded projects on the same topics.
-
Photodynamic lipids to boost chemotherapy for metastatic ovarian cancer
A patient-friendly approach tests a light-activated method to make ovarian cancer metastases more sensitive to chemotherapy.
-
Dual targeting of heart cell receptors to prevent chemotherapy heart damage
Atrial patients receiving the chemotherapy drug doxorubicin may be protected from heart damage by targeting two heart cell receptors at once.
-
A 3D ultrasound scanner to see early chemotherapy response in breast cancer
A new 3D ultrasound imaging method will be tested to see if it can quickly show whether breast cancer is responding to chemotherapy.
-
Non-invasive, microscopic biomarkers to detect CIPN in chemotherapy patients
This grant aims to develop a non-invasive imaging method to measure nerve changes in patients undergoing chemotherapy to better understand and monitor chemotherapy-induced peripheral neuropathy (CIPN).
-
Alternative NF-kB activation after chemotherapy in ovarian cancer
This grant studies how ovarian cancer might come back after chemotherapy by looking at specific signaling pathways in cancer cells and the tumor environment.
-
Genetic clues for doxorubicin heart risk using patient-derived heart cells
A research project tests how human heart cells grown from stem cells react to a common chemotherapy to see which genetic differences may raise the risk of heart damage.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.