Developing a new treatment to prevent cholera outbreaks using bacteriophages.
Official title: Manufacturing and Formulation Process Development for a Prophylactic Cholera Phage Cocktail
Funded at Phagepro, INC. · NIH-11068008 · Data updated 2026-11-12
This study is testing a special mix of viruses that can help prevent cholera, a serious illness that causes severe diarrhea, especially for people who have been around someone who is infected.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Phagepro, INC. NIH-funded |
| Lab location | 1 site (Mansfield, UNITED STATES) |
| Project start | December 16, 2024 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $1,000,000 |
| NIH project number | 1R44AI188855-01 |
| Project ID | NIH-11068008 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living in areas with high cholera prevalence or those who have been in close contact with cholera patients.
✕Less likely to help
Patients who are not at risk for cholera or those living in regions with low incidence of the disease may not benefit from this research.
What this research studies
This research focuses on creating a prophylactic cholera phage cocktail to prevent the spread of cholera, a severe diarrheal disease caused by the bacterium Vibrio cholerae. The approach involves formulating a targeted treatment that can act quickly to reduce the risk of cholera transmission in communities, especially among those who have been in contact with infected individuals. By utilizing bacteriophages, which are viruses that specifically target bacteria, this research aims to provide a novel solution to combat cholera outbreaks effectively.
Why it matters
Potential benefit: If successful, this research could significantly reduce cholera transmission and improve public health outcomes in at-risk communities.
How similar studies have gone: While the use of bacteriophages in treating bacterial infections has shown promise, this specific approach to cholera prevention is novel and has not been extensively tested.
Where this research is happening
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Phagepro, INC.
Mansfield, United States Active
Researchers
- Principal investigator: Yen, Minmin — Phagepro, INC.
- Study coordinator: Yen, Minmin
Related research
Other NIH-funded projects on the same topics.
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Prophylactic Cholera Phage Cocktail for Community Protection
A fast-acting phage-based preventive treatment called ProphaLytic-Vc is being developed to help people in cholera-prone areas avoid infection.
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Testing a new treatment to prevent cholera outbreaks using bacteriophages.
This study is testing a new treatment using special viruses that can help protect communities at risk of cholera, aiming to quickly reduce the spread of this serious illness.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.