Developing a new treatment to improve bladder and bowel control for certain patients.
Official title: LIQUID CHROMATOGRAPHY WITH TANDEM MASS SPECTROMETRY (HPLC-MS-MS) ASSAY VALIDATION AND SAMPLE TESTING
Funded at Battelle Centers/pub Hlth Res & Evaluatn · NIH-10949055 · Data updated 2026-11-12
This study is testing a new peptide drug that aims to help people with spinal injuries, multiple sclerosis, or diabetes regain better control over their bladder and bowel, which could make managing incontinence easier and improve their daily lives.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Battelle Centers/pub Hlth Res & Evaluatn NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project start | June 16, 2023 |
| Project end | June 15, 2028 |
| Funding year | 2023 |
| Award (this year) | $494,704 |
| NIH project number | 75N95022D00021-0-759502300002-1 |
| Project ID | NIH-10949055 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with spinal injuries, multiple sclerosis, or diabetes who experience bladder and bowel control problems.
✕Less likely to help
Patients without spinal injuries, multiple sclerosis, or diabetes are unlikely to benefit from this research.
What this research studies
This research focuses on creating a peptide drug that targets the neurokinin2 receptor to help restore bladder and bowel control in individuals suffering from spinal injuries, multiple sclerosis, or diabetes. The project aims to optimize a lead peptide called DTI-117 and assess its effectiveness through various pre-clinical studies and regulatory processes. Patients may benefit from this innovative approach as it could lead to improved management of incontinence and related symptoms. The research will involve both laboratory and clinical trial evaluations to ensure safety and efficacy.
Why it matters
Potential benefit: If successful, this research could significantly improve the quality of life for patients with bladder and bowel control issues.
How similar studies have gone: Other research has shown promise in developing receptor-targeted therapies for similar conditions, indicating potential success for this approach.
Where this research is happening
-
Battelle Centers/pub Hlth Res & Evaluatn
Columbus, United States Active
Researchers
- Principal investigator: Burnaugh, Amanda — Battelle Centers/pub Hlth Res & Evaluatn
- Study coordinator: Burnaugh, Amanda
Related research
Other NIH-funded projects on the same topics.
-
Testing the safety of vaccines and biologics for infectious diseases
This study is looking at new vaccines to help protect people from infectious diseases, including those that could come from bioterrorism, and aims to make these vaccines safer and more effective for everyone.
-
Developing antibody treatments for Duchenne's muscular dystrophy
This study is working on a new treatment for Duchenne's muscular dystrophy (DMD) using a special antibody, which could help improve the lives of patients by targeting the root causes of the condition.
-
Monitoring heart and blood pressure changes in animals exposed to toxic chemicals
This study is looking at how tracking heart rate and blood pressure in animals can help us spot early signs of harm from toxic chemicals, which could lead to better ways to monitor and protect people from similar dangers.
-
Creating a system to test inhalation exposure to air pollutants in the lab
This study is working on a new lab system that safely tests how different air pollutants and toxic substances affect breathing, which could help us understand their impact on people and animals without using live tests.
-
Evaluating the effects of certain flame retardants on rats during development.
This study is looking at how certain chemicals, found in some products, might affect the health and development of baby rats when their mothers are pregnant or nursing, to help keep people safe from harmful substances.
-
Evaluating the health risks of naturally occurring asbestos and related mineral fibers.
This study is looking at how breathing in natural asbestos and similar fibers might harm health, especially the lungs, using tests on lab rats, to help keep people safe from these potential dangers.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.