Developing a new treatment that combines imaging and therapy for oral cavity tumors
Dual function theranostic constructs for photoacoustic guided surgery and photodynamic therapy
This study is working on a new tool that helps doctors see and treat tongue cancers more effectively during surgery, making sure they remove the tumor while keeping healthy tissue safe.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11082999 on NIH RePORTER |
What this research studies
This research aims to create a novel theranostic agent that combines deep tissue imaging with targeted therapy for patients with oral cavity tumors, such as tongue cancers. By utilizing a Dual Function Antibody Conjugate, the project seeks to improve surgical outcomes by accurately gauging tumor depth and minimizing residual disease. The approach integrates photoacoustic imaging and ultrasound imaging to guide surgeries, ensuring that healthy tissue is preserved while effectively targeting tumors. This collaborative effort involves experts from both academic and clinical settings to enhance the treatment process for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with oral cavity tumors, particularly those with tongue cancers.
Not a fit: Patients with non-cancerous oral conditions or those not diagnosed with oral cavity tumors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve survival rates and quality of life for patients with oral cavity tumors.
How similar studies have performed: Previous research has shown promise in using imaging-guided therapies for cancer treatment, indicating potential success for this novel approach.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Hasan, Tayyaba — Massachusetts General Hospital
- Study coordinator: Hasan, Tayyaba
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.