Developing a new treatment for ovarian and kidney cancers using CAR T-cell therapy.
Preclinical development of CM-CX1 for the treatment of ovarian clear cell and renal cell carcinomas
This study is testing a new treatment called CM-CX1 that uses your own immune cells to help fight ovarian clear cell and renal cell cancers, aiming to make the treatment more effective than what’s currently available.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Celdara Medical, LLC NIH-funded |
| Lab location | 1 site (Lebanon, United States) |
| Project ID | NIH-10696145 on NIH RePORTER |
What this research studies
This research focuses on creating a novel CAR T-cell therapy called CM-CX1, which aims to treat ovarian clear cell and renal cell carcinomas. The approach involves genetically modifying a patient's own T cells to target a specific marker found in these cancers, enhancing the immune system's ability to fight the disease. By utilizing the body's natural defenses, this therapy seeks to provide a more effective treatment option compared to traditional methods. The research is currently in the preclinical phase, preparing for human trials.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with ovarian clear cell carcinoma or renal cell carcinoma who may benefit from innovative immunotherapy approaches.
Not a fit: Patients with cancers that do not express the TIM-1 marker or those who are not eligible for CAR T-cell therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a groundbreaking treatment option for patients with ovarian and renal cancers, potentially improving survival rates and quality of life.
How similar studies have performed: Previous research has shown promise in using CAR T-cell therapy for various cancers, indicating a potential for success with this novel approach.
Where this research is happening
Lebanon, United States
- Celdara Medical, LLC — Lebanon, United States (Active)
Researchers
- Principal investigator: Murad, Joana M — Celdara Medical, LLC
- Study coordinator: Murad, Joana M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.