Developing a new treatment for nerve pain without opioids
Optimization of an HCN1-Selective Inverse Agonist for the Treatment of Peripheral Neuropathic Pain
This study is looking for a new medicine to help adults with chronic nerve pain feel better, using a special approach that targets overactive nerve channels without the risks of opioids, so patients can find relief and improve their quality of life.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Akelos INC. NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10709890 on NIH RePORTER |
What this research studies
This research focuses on creating a new medication to treat peripheral neuropathic pain, which affects many adults suffering from chronic pain. The approach involves optimizing a specific compound that targets hyperactive nerve channels, aiming to provide relief without the risks associated with opioid medications. By screening a library of compounds, the researchers hope to identify a potent and selective treatment that can alleviate pain while minimizing side effects. This innovative strategy seeks to improve the quality of life for patients dealing with chronic nerve pain.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who suffer from peripheral neuropathic pain.
Not a fit: Patients who do not experience neuropathic pain or those who are not adults may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a safer, non-opioid alternative for managing chronic nerve pain.
How similar studies have performed: Similar research has shown promise in developing non-opioid treatments for pain management, indicating a potential for success in this novel approach.
Where this research is happening
New York, United States
- Akelos INC. — New York, United States (Active)
Researchers
- Principal investigator: Fox, Steven R — Akelos INC.
- Study coordinator: Fox, Steven R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.