Developing a new treatment for acute pancreatitis in dogs and humans
Official title: One Health Advancement of RABI-767 for the Management of Acute Pancreatitis
Funded at Lamassu Pharma INC. · NIH-10921425 · Data updated 2026-11-12
This study is exploring a new treatment for acute pancreatitis, a serious condition that currently has no good options, by testing a promising compound called RABI-767 in dogs to see how well it works and is tolerated, which will help us develop better therapies for both dogs and people in the future.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lamassu Pharma INC. NIH-funded |
| Lab location | 1 site (Durham, UNITED STATES) |
| Project start | July 7, 2020 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $873,744 |
| NIH project number | 2R44DK125219-03 |
| Project ID | NIH-10921425 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include dogs diagnosed with spontaneous acute pancreatitis and potentially humans with the same condition in future trials.
✕Less likely to help
Patients with chronic pancreatitis or those not diagnosed with acute pancreatitis may not benefit from this research.
What this research studies
This research focuses on creating a novel therapy for acute pancreatitis, a serious condition with no effective treatments available. The approach is based on understanding how fat breakdown and toxicity contribute to the severity of the disease. The research involves testing a lead compound, RABI-767, in canine models to evaluate its effectiveness and safety, which will also inform future human clinical trials. The study aims to optimize dosing schedules to improve treatment outcomes for both dogs and humans suffering from this condition.
Why it matters
Potential benefit: If successful, this research could lead to a new effective treatment for acute pancreatitis, significantly improving patient outcomes.
How similar studies have gone: Previous research has shown promise in using similar therapeutic approaches for treating acute pancreatitis, indicating potential for success in this novel treatment.
Where this research is happening
-
Lamassu Pharma INC.
Durham, United States Active
Researchers
- Principal investigator: Hanna, Gabi — Lamassu Pharma INC.
- Study coordinator: Hanna, Gabi
Related research
Other NIH-funded projects on the same topics.
-
Diabetes after acute pancreatitis: understanding and tracking progression
A patient-focused look at how diabetes can develop after an episode of acute pancreatitis, using data from a large, ongoing study and AI insights.
-
Continuation of Type 1 Diabetes in Acute Pancreatitis: UF Health and AdventHealth
A patient-facing overview of a long-term study tracking people with acute pancreatitis to understand how some develop type 1 diabetes later and what factors influence that process.
-
Data Coordinating Center for Type 1 Diabetes in Acute Pancreatitis Consortium
A national effort to learn how pancreatitis-related Type 1 diabetes develops, by tracking patients and coordinating data to improve future care.
-
Diabetes after acute pancreatitis: a patient-focused network study
A program at Indiana University is studying how diabetes can develop after an acute pancreatitis episode, with new findings that could help doctors tailor care for adults who had pancreatitis.
-
Type 1 Diabetes in Acute Pancreatitis in Diabetes Patients at Stanford
A Stanford-led project helps people with brittle type 1 diabetes who also experience pancreatitis by following them in a long-term study to understand how acute pancreatitis affects diabetes.
-
Epidemiology and causes of diabetes after acute pancreatitis
A long-term study following people who have had acute pancreatitis to understand how often diabetes develops, why it happens, and how it progresses.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.