Developing a new tool for examining tissue samples without dyes
Official title: Label-free digital cytopathology using deep-ultraviolet coded ptychography with intrinsic molecular contrast
Funded at University of Connecticut Storrs · NIH-10870053 · Data updated 2026-11-12
This study is testing a new digital tool that uses special light to look at tissue samples without needing dyes, which could help doctors get faster and more accurate results for diagnosing conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $355,755 |
| NIH project number | 5R01EB034744-02 |
| Project ID | NIH-10870053 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals requiring histopathological examination of tissue samples, such as those with suspected tumors or other cellular abnormalities.
✕Less likely to help
Patients who do not require tissue analysis or those with conditions that do not involve cellular examination may not benefit from this research.
What this research studies
This research focuses on creating a novel digital cytopathology tool that allows for the examination of tissue samples without the need for traditional dye staining. By utilizing deep-ultraviolet light, the tool can directly interact with the biomolecules in cells, providing detailed information about their structure and composition. This method aims to significantly reduce the time required for histopathological analysis, enabling quicker diagnosis and treatment decisions. The approach involves advanced imaging techniques that do not rely on conventional microscopy, making it a potentially transformative technology in medical diagnostics.
Why it matters
Potential benefit: If successful, this research could lead to faster and more accurate diagnoses for patients, improving treatment outcomes.
How similar studies have gone: While the approach of using deep-ultraviolet light for cytopathology is innovative, similar techniques in other imaging modalities have shown promise in enhancing diagnostic capabilities.
Where this research is happening
-
University of Connecticut Storrs
Storrs-Mansfield, United States Active
Researchers
- Principal investigator: Zheng, Guoan — University of Connecticut Storrs
- Study coordinator: Zheng, Guoan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.