Developing a new tool for analyzing lipids in tissue samples using lasers
Official title: Photochemical Tissue Modification for MALDI Mass Spectrometry Imaging
Funded at Laser Bioanalytics LLC · NIH-11005360 · Data updated 2026-11-12
This study is testing a new tool that uses lasers to change certain fats in tissue samples, helping doctors get better information about these fats to improve how they diagnose and understand different diseases.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Laser Bioanalytics LLC NIH-funded |
| Lab location | 1 site (Baton Rouge, United States) |
| Project start | September 15, 2024 |
| Project end | September 14, 2025 |
| Funding year | 2024 |
| Award (this year) | $304,196 |
| NIH project number | 1R43GM156259-01 |
| Project ID | NIH-11005360 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to lipid metabolism or cardiovascular diseases.
✕Less likely to help
Patients with conditions unrelated to lipid metabolism or those not requiring detailed lipid analysis may not benefit from this research.
What this research studies
This research focuses on creating a prototype instrument that uses focused laser beams to chemically modify lipids in tissue sections. By tagging specific locations of lipid double bonds, the modified tissues can then be analyzed using advanced mass spectrometry techniques. This approach aims to enhance the ability to identify and quantify lipids, which are crucial for understanding various diseases. Patients may benefit from improved diagnostic methods that provide more detailed insights into their conditions.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and treatments for diseases related to lipid abnormalities.
How similar studies have gone: While the approach of using photochemical reactions for lipid analysis is innovative, similar techniques in mass spectrometry have shown promise in other contexts.
Where this research is happening
-
Laser Bioanalytics LLC
Baton Rouge, United States Active
Researchers
- Principal investigator: Murray, Kermit King — Laser Bioanalytics LLC
- Study coordinator: Murray, Kermit King
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.