Developing a new test to find drugs that help treat Alzheimer's disease
Official title: On-Chip Assay for Identifying Candidate Microtubule Binding Drugs to Treat ADRDs
Funded at Neuroindx INC. · NIH-10920056 · Data updated 2026-11-12
This study is working on a new way to test potential drugs that could help stabilize important structures in brain cells, which may lead to better treatments for Alzheimer's disease and similar conditions.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Neuroindx INC. NIH-funded |
| Lab location | 1 site (Torrance, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $514,862 |
| NIH project number | 1R43AG085842-01A1 |
| Project ID | NIH-10920056 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias who may benefit from new therapeutic options.
✕Less likely to help
Patients with non-neurodegenerative forms of dementia or those not diagnosed with Alzheimer's disease may not receive any benefit from this research.
What this research studies
This research focuses on creating an innovative on-chip assay that mimics the environment of neurons to identify potential drugs that can stabilize microtubules, which are crucial for neuron function. By using this advanced technology, researchers aim to streamline the process of discovering effective treatments for Alzheimer's disease and related dementias, moving away from traditional methods that rely on cell cultures and animal models. The assay will specifically test how well candidate drugs can interact with microtubules and improve their function, potentially leading to new therapies for neurodegeneration.
Why it matters
Potential benefit: If successful, this research could lead to the development of new drugs that effectively treat Alzheimer's disease and improve the quality of life for patients.
How similar studies have gone: Other research has shown promise in using similar on-chip technologies for drug discovery, indicating potential for success in this novel approach.
Where this research is happening
-
Neuroindx INC.
Torrance, United States Active
Researchers
- Principal investigator: Karsten, Stanislav — Neuroindx INC.
- Study coordinator: Karsten, Stanislav
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.