Developing a new technology to sequence RNA editing products
Official title: Nanoscale Tools for Inosine Sequencing
Funded at Electronic Biosciences, INC. · NIH-10651806 · Data updated 2026-11-12
This study is working on a new way to look at RNA, which is important for understanding how our genes work and how they can change in diseases like Alzheimer's and cancer, with the hope that it will help improve diagnosis and treatment for patients.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Electronic Biosciences, INC. NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | July 1, 2022 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $1,000,000 |
| NIH project number | 5R44HG012409-02 |
| Project ID | NIH-10651806 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by Alzheimer's disease or cancers where RNA editing plays a significant role.
✕Less likely to help
Patients with conditions unrelated to RNA editing or those not affected by Alzheimer's or specific cancers may not benefit from this research.
What this research studies
This research focuses on creating an innovative RNA sequencing technology that can directly identify inosine, a product of RNA editing. By converting adenosine to inosine, cells can alter the coding potential of their mRNA, which is crucial for understanding various diseases, including Alzheimer's and certain cancers. The project aims to develop a single-molecule sequencing technique that accurately profiles RNA editing, thereby enhancing our understanding of RNA function and its implications in disease. This technology could lead to improved diagnostics and treatments by providing insights into the role of RNA editing in health and disease.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and therapies for diseases like Alzheimer's and certain cancers.
How similar studies have gone: Other research has shown promise in RNA sequencing technologies, but this specific approach to directly sequence inosine is relatively novel.
Where this research is happening
-
Electronic Biosciences, INC.
San Diego, United States Active
Researchers
- Principal investigator: Ervin, Eric — Electronic Biosciences, INC.
- Study coordinator: Ervin, Eric
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.