Developing a new T cell vaccine to fight malaria
Human-informed data-driven development of next-generation T cell vaccine against malaria
['FUNDING_R01'] · UNIVERSITY OF QUEENSLAND · NIH-10696142
This study is working on a new malaria vaccine that helps your immune system fight off the disease better by finding special parts of the malaria parasite that can boost your body's defenses.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF QUEENSLAND (nih funded) |
| Locations | 1 site (BRISBANE, AUSTRALIA) |
| Trial ID | NIH-10696142 on ClinicalTrials.gov |
What this research studies
This research aims to create a next-generation vaccine against malaria by identifying key antigens that stimulate T cell responses. The approach involves screening the complete Plasmodium falciparum parasite proteome to find specific antigens that can trigger protective immunity. By focusing on CD8+ T cells, which play a crucial role in attacking the malaria parasite during its early stages, the research seeks to enhance the effectiveness of malaria vaccination. The ultimate goal is to develop a vaccine that can prevent malaria infections and reduce the disease's global impact.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living in malaria-endemic regions who are at risk of infection.
Not a fit: Patients who are not at risk of malaria or those who have already been vaccinated against malaria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a highly effective malaria vaccine, significantly reducing the number of malaria cases and deaths worldwide.
How similar studies have performed: Previous research has shown promise in developing malaria vaccines using similar approaches, indicating potential for success in this novel investigation.
Where this research is happening
BRISBANE, AUSTRALIA
- UNIVERSITY OF QUEENSLAND — BRISBANE, AUSTRALIA (ACTIVE)
Researchers
- Principal investigator: DOOLAN, DENISE L. — UNIVERSITY OF QUEENSLAND
- Study coordinator: DOOLAN, DENISE L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.