Developing a new system to assess heart tissue during atrial fibrillation treatment
Official title: Intraoperative Pulsed Field Ablation and Lesion Assessment System
Funded at Sigt, LLC · NIH-10762116 · Data updated 2026-11-12
This study is working on a new way to make heart treatments for atrial fibrillation safer and more effective by using special technology to check the heart tissue during a procedure, helping doctors ensure that the treatment works well for patients.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sigt, LLC NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $293,880 |
| NIH project number | 1R43HL170906-01 |
| Project ID | NIH-10762116 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with atrial fibrillation who may require treatment through ablation procedures.
✕Less likely to help
Patients with atrial fibrillation who are not candidates for ablation procedures or those with other underlying health conditions may not benefit from this research.
What this research studies
This research focuses on improving the treatment of atrial fibrillation (AF) by developing a novel system that can assess heart tissue during a procedure called Pulsed Electric Field Ablation (PFA). The approach involves using high-frequency dielectric sensing technology to measure the electrical properties of heart tissue in real-time, ensuring that the lesions created during the procedure are effective and durable. By enhancing the ability to monitor and confirm successful lesion formation, this research aims to improve the safety and efficacy of AF treatments for patients. The project is in its early phase and aims to create a prototype that can be tested in clinical settings.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatments for patients suffering from atrial fibrillation.
How similar studies have gone: While the use of pulsed electric field ablation is promising, the specific approach of using high-frequency dielectric sensing for intraoperative assessment is novel and has not been extensively tested in previous studies.
Where this research is happening
-
Sigt, LLC
Columbia, United States Active
Researchers
- Principal investigator: Karmarkar, Parag — Sigt, LLC
- Study coordinator: Karmarkar, Parag
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.