Developing a new RNA-based vaccine for avian influenza
Official title: Rapid response to pandemic influenza via multi-antigen RNA-based vaccine
Funded at Tiba Biotech, LLC · NIH-10920420 · Data updated 2026-11-12
This study is testing a new type of vaccine for the H7N9 bird flu virus, which can cause serious illness, to see if it can create a strong immune response with fewer side effects, and it's aimed at helping people stay safe during outbreaks.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tiba Biotech, LLC NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | February 10, 2022 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $965,678 |
| NIH project number | 5R44AI167158-03 |
| Project ID | NIH-10920420 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at high risk for avian influenza exposure, such as poultry workers or those in close contact with birds.
✕Less likely to help
Patients who are not at risk for avian influenza or those who have already been vaccinated against it may not benefit from this research.
What this research studies
This research focuses on creating a rapid-response vaccine for the avian influenza A H7N9 virus, which poses a significant risk of severe respiratory illness and potential pandemics. The approach utilizes a novel RNA vaccine technology that aims to induce strong immune responses with less inflammation compared to traditional vaccines. By using a proprietary delivery system, the researchers hope to improve vaccine stability and effectiveness, making it easier to deploy during health crises. The study involves preclinical testing in mice to evaluate the immune response generated by the vaccine formulation.
Why it matters
Potential benefit: If successful, this research could lead to a more effective and rapidly deployable vaccine for avian influenza, potentially saving lives during future outbreaks.
How similar studies have gone: Other research has shown promise in using RNA vaccine technology for rapid responses to viral outbreaks, particularly during the COVID-19 pandemic.
Where this research is happening
-
Tiba Biotech, LLC
Cambridge, United States Active
Researchers
- Principal investigator: Chahal, Jasdave — Tiba Biotech, LLC
- Study coordinator: Chahal, Jasdave
Related research
Other NIH-funded projects on the same topics.
-
Creating vaccines for influenza and other infectious diseases
This study is all about creating new vaccines to help protect people from the flu and other infections, so patients can look forward to better options for staying healthy.
-
Creating vaccines for human trials against influenza and other infectious diseases
This study is working on creating new vaccines to help protect people from flu and other infectious diseases, including those that could be used in harmful situations, so that everyone can have safer and more effective options to stay healthy.
-
Understanding flu and COVID-19 vaccine responses in people and in the lab
Researchers at Stanford explore how flu and COVID-19 vaccines work in people and in lab tests to improve protection for adults.
-
Surveillance and preparedness for flu and other respiratory pathogens in Kenya
A US-based research grant aims to improve how Kenya detects and prepares for influenza and other respiratory diseases to protect people there and global health.
-
Enhanced Seasonal Influenza Vaccine Targeting Shared and Variable Viral Antigens
A new DNA-based influenza vaccine approach aims to provide both precise protection against circulating strains and broader defense against unexpected strains.
-
How the immune system responds to flu shots and flu infection
This project looks at how adults' immune systems react after flu shots or when they catch the flu to find why some people get better protection than others.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.