Developing a new platform for testing Alzheimer's disease treatments using mini-brains.
NanoLuciferase-based AD/ADRD Microphysiological Systems Platform for High-throughput Screening
['FUNDING_OTHER'] · NEUCYTE, INC. · NIH-10823023
This study is working on a special lab model of the human brain to help find better treatments for Alzheimer's disease by using tiny brain-like structures made from patients' own cells.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEUCYTE, INC. (nih funded) |
| Locations | 1 site (MOUNTAIN VIEW, UNITED STATES) |
| Trial ID | NIH-10823023 on ClinicalTrials.gov |
What this research studies
This research focuses on creating a microphysiological system that mimics the human brain to better understand and test potential treatments for Alzheimer's disease. By using human-induced pluripotent stem cells from patients with specific genetic backgrounds, the researchers aim to develop mini-brain organoids that can accurately represent the disease environment. This innovative approach allows for high-throughput screening of therapeutic compounds, potentially leading to more effective treatments for Alzheimer's and related dementias.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Alzheimer's disease or those at risk due to genetic factors, particularly those carrying the APOE4 allele.
Not a fit: Patients with non-Alzheimer's related dementias or those without genetic predispositions to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective therapies for Alzheimer's disease, improving patient outcomes.
How similar studies have performed: Previous research using human-induced pluripotent stem cells and microphysiological systems has shown promise in modeling diseases and testing therapies, indicating a potential for success in this novel approach.
Where this research is happening
MOUNTAIN VIEW, UNITED STATES
- NEUCYTE, INC. — MOUNTAIN VIEW, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: POON, WAYNE W — NEUCYTE, INC.
- Study coordinator: POON, WAYNE W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer disease screening