Developing a new platform for testing Alzheimer's disease treatments using mini-brains.
Official title: NanoLuciferase-based AD/ADRD Microphysiological Systems Platform for High-throughput Screening
Funded at Neucyte, INC. · NIH-10823023 · Data updated 2026-11-12
This study is working on a special lab model of the human brain to help find better treatments for Alzheimer's disease by using tiny brain-like structures made from patients' own cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Neucyte, INC. NIH-funded |
| Lab location | 1 site (Mountain View, United States) |
| Project start | September 15, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $500,000 |
| NIH project number | 1R41AG085831-01 |
| Project ID | NIH-10823023 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with Alzheimer's disease or those at risk due to genetic factors, particularly those carrying the APOE4 allele.
✕Less likely to help
Patients with non-Alzheimer's related dementias or those without genetic predispositions to Alzheimer's may not benefit from this research.
What this research studies
This research focuses on creating a microphysiological system that mimics the human brain to better understand and test potential treatments for Alzheimer's disease. By using human-induced pluripotent stem cells from patients with specific genetic backgrounds, the researchers aim to develop mini-brain organoids that can accurately represent the disease environment. This innovative approach allows for high-throughput screening of therapeutic compounds, potentially leading to more effective treatments for Alzheimer's and related dementias.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective therapies for Alzheimer's disease, improving patient outcomes.
How similar studies have gone: Previous research using human-induced pluripotent stem cells and microphysiological systems has shown promise in modeling diseases and testing therapies, indicating a potential for success in this novel approach.
Where this research is happening
-
Neucyte, INC.
Mountain View, United States Active
Researchers
- Principal investigator: Poon, Wayne W — Neucyte, INC.
- Study coordinator: Poon, Wayne W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.