Developing a new optical interface to control nerve activity
Optimization of a Minimally-Invasive Bidirectional Optogenetic Peripheral Nerve Interface with Single Axon Read-in & Read-out Specificity
['FUNDING_R01'] · UNIVERSITY OF COLORADO DENVER · NIH-11128432
This study is exploring a new, gentle device that uses light to help control and monitor nerve activity, which could lead to better treatments for conditions like epilepsy and metabolic disorders, starting with tests in specially modified mice before moving to humans.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-11128432 on ClinicalTrials.gov |
What this research studies
This research focuses on creating a minimally-invasive device that can optically stimulate and monitor individual nerve fibers in the peripheral nervous system. By using advanced techniques like optogenetics, the researchers aim to modulate nerve activity non-invasively, which could lead to new treatments for conditions such as epilepsy and metabolic disorders. The approach involves genetically modifying neurons to express light-sensitive proteins, allowing for precise control of nerve signaling. The initial testing will be conducted in transgenic mice before considering applications in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research would include individuals suffering from epilepsy or metabolic disorders that could benefit from neuromodulation therapies.
Not a fit: Patients with conditions unrelated to the vagus nerve or those who do not respond to neuromodulation therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies for patients with neurological disorders and improve the management of conditions related to the vagus nerve.
How similar studies have performed: While the use of optogenetics in nerve modulation is a relatively novel approach, preliminary studies have shown promise in similar applications.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WEIR, RICHARD FERGUS FFRENCH — UNIVERSITY OF COLORADO DENVER
- Study coordinator: WEIR, RICHARD FERGUS FFRENCH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease