Developing a new non-hormonal contraceptive for men
Reversible male contraception by inhibition of serine/threonine kinase 33
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-11146641
This study is working on a new kind of birth control for men that safely stops sperm production without using hormones, and it's looking for the best compounds to make this possible.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11146641 on ClinicalTrials.gov |
What this research studies
This research aims to create a new type of male contraceptive that works by inhibiting a specific enzyme called serine/threonine kinase 33 (STK33). The approach involves preclinical drug development studies to identify potent and selective inhibitors that can effectively block this enzyme without hormonal side effects. By using advanced screening techniques, the researchers are exploring a vast library of compounds to find those that can safely and effectively prevent sperm production. If successful, this could lead to a new contraceptive option for men that is reversible and does not rely on hormones.
Who could benefit from this research
Good fit: Ideal candidates for this research are adult men who are seeking reversible contraception methods.
Not a fit: Patients who are not male or those who are not interested in contraception may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide men with a safe and effective non-hormonal contraceptive option.
How similar studies have performed: While the concept of targeting STK33 for male contraception is relatively novel, other research has successfully developed kinase inhibitors for various therapeutic applications.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MATZUK, MARTIN M. — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: MATZUK, MARTIN M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.