Developing a new microscope for high-resolution live imaging
Official title: Three-dimensional Nonlinear Structured Illumination for Live Imaging with 80 nm resolution
Funded at University of Georgia · NIH-10913974 · Data updated 2026-11-12
This study is working on a new type of microscope that can take super clear pictures of living cells, which could help doctors better understand how our cells work and what goes wrong in diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | September 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $298,399 |
| NIH project number | 5R01GM149978-02 |
| Project ID | NIH-10913974 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve cellular dysfunction or abnormalities, such as cancer or neurodegenerative diseases.
✕Less likely to help
Patients with conditions unrelated to cellular imaging or those not requiring advanced imaging techniques may not benefit from this research.
What this research studies
This research focuses on creating an advanced microscope that can capture live images of biological samples with an impressive resolution of 80 nanometers. By utilizing a technique called Three-dimensional Nonlinear Structured Illumination Microscopy, the researchers aim to improve the speed and efficiency of imaging while maintaining high resolution. This approach requires fewer raw images compared to traditional methods, making it suitable for observing dynamic processes in living cells. Patients may benefit from enhanced understanding of cellular functions and disease mechanisms through improved imaging techniques.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding cellular processes and diseases, ultimately improving patient diagnosis and treatment.
How similar studies have gone: Previous research has shown promising results with similar imaging techniques, indicating potential for success in this novel approach.
Where this research is happening
-
University of Georgia
Athens, United States Active
Researchers
- Principal investigator: Kner, Peter Alexander — University of Georgia
- Study coordinator: Kner, Peter Alexander
Related research
Other NIH-funded projects on the same topics.
-
BRD4 and NIPBL work together to control facial bone development
A study in mice and cell models will explore how BRD4 and NIPBL work together to control how genes are turned on in facial development, which could clarify causes of craniofacial disorders.
-
Sulfated glycosaminoglycan hydrogels to protect brain volume after traumatic injury
A new implantable gel made from specially sulfated sugars may help prevent brain shrinkage and improve function after a serious brain injury.
-
Understanding how Kaposi’s sarcoma virus switches on late genes during infection
Scientists are studying how the virus causing Kaposi’s sarcoma turns on late genes when its DNA copies itself, which could reveal new ways to treat cancer in people with AIDS.
-
Understanding how cells control signals and adhesion with the secretory pathway
A funded NIH project looks at how the cell’s secretory system shapes signals, receptors, and attachment to the outside of the cell, which can influence many human diseases.
-
AI-powered math and machine learning for bioscience and drug discovery
A broad NIH grant supports using advanced math and AI to better predict viral variants and aid drug discovery, with the goal of helping patients by accelerating pandemic response.
-
AI-driven platform to predict vaccine-escape variants and design mutation-proof antibodies
An AI-powered approach aims to anticipate SARS-CoV-2 variants that may dodge vaccines and to create antibodies that stay effective.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.