Developing a new microscope for high-resolution live imaging

Three-dimensional Nonlinear Structured Illumination for Live Imaging with 80 nm resolution

['FUNDING_R01'] · UNIVERSITY OF GEORGIA · NIH-10913974

This study is working on a new type of microscope that can take super clear pictures of living cells, which could help doctors better understand how our cells work and what goes wrong in diseases.

Quick facts

Phase['FUNDING_R01']
Study typeNih_funding
SexAll
SponsorUNIVERSITY OF GEORGIA (nih funded)
Locations1 site (ATHENS, UNITED STATES)
Trial IDNIH-10913974 on ClinicalTrials.gov

What this research studies

This research focuses on creating an advanced microscope that can capture live images of biological samples with an impressive resolution of 80 nanometers. By utilizing a technique called Three-dimensional Nonlinear Structured Illumination Microscopy, the researchers aim to improve the speed and efficiency of imaging while maintaining high resolution. This approach requires fewer raw images compared to traditional methods, making it suitable for observing dynamic processes in living cells. Patients may benefit from enhanced understanding of cellular functions and disease mechanisms through improved imaging techniques.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals with conditions that involve cellular dysfunction or abnormalities, such as cancer or neurodegenerative diseases.

Not a fit: Patients with conditions unrelated to cellular imaging or those not requiring advanced imaging techniques may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to breakthroughs in understanding cellular processes and diseases, ultimately improving patient diagnosis and treatment.

How similar studies have performed: Previous research has shown promising results with similar imaging techniques, indicating potential for success in this novel approach.

Where this research is happening

ATHENS, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.