Developing a new method to sterilize drugs using carbon dioxide

NovaAPI: Terminal Sterilization of Drug Substances and Products

['FUNDING_SBIR_2'] · NOVASTERILIS, INC. · NIH-11013394

This study is testing a new way to sterilize medicines using a special gas and a strong cleaning agent to make sure they are safe and effective for patients, helping drug makers improve their processes.

Quick facts

Phase['FUNDING_SBIR_2']
Study typeNih_funding
SexAll
SponsorNOVASTERILIS, INC. (nih funded)
Locations1 site (LANSING, UNITED STATES)
Trial IDNIH-11013394 on ClinicalTrials.gov

What this research studies

This research focuses on creating a novel sterilization platform that utilizes supercritical carbon dioxide and a powerful sterilant called NovaKill™ to effectively sterilize drug substances and products. The goal is to improve the terminal sterilization process, which is crucial for ensuring the safety and efficacy of pharmaceuticals. By addressing the limitations of current sterilization methods, this research aims to provide a more efficient and reliable solution for drug manufacturers, ultimately benefiting patients who rely on sterile medications.

Who could benefit from this research

Good fit: Ideal candidates for benefiting from this research include patients who require sterile medications, such as those receiving injectable biologics or other pharmaceuticals.

Not a fit: Patients who do not require sterile medications or those using non-sterile drug formulations may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to safer and more effective sterilization methods for pharmaceuticals, enhancing patient safety.

How similar studies have performed: Other research has shown success with innovative sterilization methods, indicating potential for this approach to also yield positive results.

Where this research is happening

LANSING, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.