Developing a new method to select and deliver aptamers for treating inflammation
Official title: Three-dimensional One-step Aptamer Selection in the Non-fouling Macroporous Hydrogel
Funded at Pennsylvania State University, the · NIH-11179148 · Data updated 2026-11-12
This study is exploring a new way to develop tiny molecules that can target and help treat inflammation in the body, aiming to create better treatments for people with immune disorders using a special delivery method.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project start | September 1, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $468,177 |
| NIH project number | 5R01GM154105-02 |
| Project ID | NIH-11179148 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with inflammatory diseases or immune disorders who may benefit from targeted aptamer therapies.
✕Less likely to help
Patients with conditions unrelated to inflammation or immune response may not receive any benefit from this research.
What this research studies
This research focuses on creating a novel approach to select and refine nucleic acid aptamers, which are small molecules that can bind to specific targets in the body. The project aims to enhance the effectiveness of these aptamers for various biomedical applications, particularly in treating inflammation. By using an innovative method for aptamer selection and testing their delivery through microneedles in animal models, the researchers hope to improve the precision and efficacy of treatments for immune disorders. Patients may benefit from more targeted therapies that can reduce inflammation and improve health outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from inflammatory conditions and immune disorders.
How similar studies have gone: Previous research has shown promise in using aptamers for targeted therapies, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
-
Pennsylvania State University, the
University Park, United States Active
Researchers
- Principal investigator: Wang, Yong — Pennsylvania State University, the
- Study coordinator: Wang, Yong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.