Developing a new method to read protein sequences using nanopores
Towards Single-Molecule Protein Sequencing with Nanopores
This study is working on a new way to read proteins one at a time using tiny holes, which could help doctors understand diseases better and improve tests and treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10892815 on NIH RePORTER |
What this research studies
This research focuses on creating a groundbreaking technology for sequencing proteins at the single-molecule level using nanopore technology. By reading individual peptide molecules without the need for chemical labeling, the method aims to achieve high accuracy in detecting amino acid substitutions. The approach leverages existing nanopore sequencing hardware and is designed to be adaptable for various applications in protein analysis, including understanding complex biological processes and diseases. Patients may benefit from advancements in proteomics that could lead to better diagnostics and treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to protein misfolding or post-translational modifications, such as certain cancers or neurodegenerative diseases.
Not a fit: Patients with conditions unrelated to protein sequencing or those who do not have specific protein-related disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly enhance our ability to analyze proteins, leading to improved disease understanding and treatment options for patients.
How similar studies have performed: Previous research in nanopore sequencing has shown promising results, indicating that this approach could lead to significant advancements in proteomics.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Gundlach, Jens — University of Washington
- Study coordinator: Gundlach, Jens
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.