Developing a new method to quickly determine protein structures using NMR
Official title: Method development for simultaneous automatic assignment and structure determination in protein NMR
Funded at Rensselaer Polytechnic Institute · NIH-10700808 · Data updated 2026-11-12
This study is working on a new way to quickly figure out the shapes and details of proteins using a technique called NMR spectroscopy, which could help scientists learn more about how proteins work and lead to better treatments for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rensselaer Polytechnic Institute NIH-funded |
| Lab location | 1 site (Troy, United States) |
| Project start | September 12, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $192,814 |
| NIH project number | 5R21GM143507-02 |
| Project ID | NIH-10700808 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with conditions related to protein misfolding or dysfunction, such as certain genetic disorders or neurodegenerative diseases.
✕Less likely to help
Patients with conditions unrelated to protein structure or function may not receive direct benefits from this research.
What this research studies
This research focuses on improving the process of determining protein structures and resonance assignments using Nuclear Magnetic Resonance (NMR) spectroscopy. By utilizing advanced mathematical techniques, the team aims to create a method that can simultaneously analyze protein structures and their resonance assignments from NMR data, which is currently a time-consuming task. The approach involves both synthetic data and real experimental data to validate the effectiveness of the new method. Patients may benefit indirectly through advancements in understanding protein functions and interactions that could lead to new treatments.
Why it matters
Potential benefit: If successful, this research could significantly speed up the process of understanding protein structures, potentially leading to new therapies for various diseases.
How similar studies have gone: Other research has shown promise in using advanced mathematical techniques for protein structure determination, indicating that this approach could be a meaningful advancement in the field.
Where this research is happening
-
Rensselaer Polytechnic Institute
Troy, United States Active
Researchers
- Principal investigator: Wang, Chunyu — Rensselaer Polytechnic Institute
- Study coordinator: Wang, Chunyu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.