Developing a new method to extract chromatin from preserved tissue samples
Official title: Development of nanodroplet enhanced ultrasonic cavitation technologyto enable the study of chromatin accessibility in FFPE tissues
Funded at Triangle Biotechnology, INC. · NIH-10699112 · Data updated 2026-11-12
This study is testing a new tool called ChromExtract™ that helps scientists get better samples from preserved tissue, which could lead to a deeper understanding of how certain diseases work and how our cells behave, ultimately benefiting patients like you.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Triangle Biotechnology, INC. NIH-funded |
| Lab location | 1 site (Chapel Hill, UNITED STATES) |
| Project start | August 15, 2023 |
| Project end | August 14, 2025 |
| Funding year | 2023 |
| Award (this year) | $339,300 |
| NIH project number | 1R43GM150348-01 |
| Project ID | NIH-10699112 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with preserved tissue samples from previous medical procedures, particularly those with conditions related to chromatin alterations.
✕Less likely to help
Patients without preserved tissue samples or those not affected by conditions related to chromatin accessibility may not benefit from this research.
What this research studies
This research focuses on creating ChromExtract™, a novel nanodroplet-based reagent designed to enhance the extraction of chromatin from formalin-fixed paraffin-embedded (FFPE) tissues. By improving the quality and yield of chromatin extraction, this method aims to facilitate more reliable epigenomic profiling and analyses. Patients can benefit from this research as it seeks to enable better understanding of how chromatin accessibility affects diseases and cell identity. The approach involves using advanced sonication techniques to overcome existing challenges in chromatin extraction, which is crucial for studying various health conditions.
Why it matters
Potential benefit: If successful, this research could lead to more accurate epigenomic analyses, improving diagnostics and treatment strategies for various diseases.
How similar studies have gone: While chromatin profiling has been studied for decades, this specific approach using nanodroplet technology is novel and has not been extensively tested in this context.
Where this research is happening
-
Triangle Biotechnology, INC.
Chapel Hill, United States Active
Researchers
- Principal investigator: Allison, David F — Triangle Biotechnology, INC.
- Study coordinator: Allison, David F
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-
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.