Developing a new method to discover therapeutic antibodies
Official title: De novo proteomics platform for therapeutic antibody discovery
Funded at University of Nebraska Lincoln · NIH-11202211 · Data updated 2026-11-12
This study is working on a new way to find and understand antibodies in your blood that can help treat diseases like cancer and infections, with the goal of discovering better treatments for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Lincoln NIH-funded |
| Lab location | 1 site (Lincoln, United States) |
| Project start | September 20, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $164,139 |
| NIH project number | 5P20GM113126-09 |
| Project ID | NIH-11202211 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients with conditions that require monoclonal antibody treatments, such as certain cancers or autoimmune diseases.
✕Less likely to help
Patients who do not require monoclonal antibody therapies or have conditions unrelated to antibody responses may not benefit from this research.
What this research studies
This research focuses on creating a novel platform for identifying and sequencing therapeutic antibodies, which are crucial for treating various diseases, including cancers and infections. The approach involves advanced techniques to accurately determine the structure of antibodies in patient serum, allowing for a better understanding of the immune response. By improving the methods for sequencing antibody components, the research aims to enhance the discovery of new monoclonal antibodies that can be used in treatments. Patients may benefit from more effective therapies derived from these discoveries.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective monoclonal antibody therapies for various diseases.
How similar studies have gone: Other research has shown promise in developing advanced proteomics methods for antibody discovery, indicating potential for success in this novel approach.
Where this research is happening
-
University of Nebraska Lincoln
Lincoln, United States Active
Researchers
- Principal investigator: Shaw, Jared Bryan — University of Nebraska Lincoln
- Study coordinator: Shaw, Jared Bryan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.