Developing a new method for faster and more accurate DNA sequencing
Official title: Super-resolution single-molecule sequencing by observing the dynamic hybridization of a repertoire of oligonucleotides to DNA targets
Funded at Xgenomes Corp. · NIH-11008187 · Data updated 2026-11-12
This study is working on a new way to read DNA that could make it easier and cheaper to track conditions like cancer and genetic disorders, using special imaging techniques to get more accurate results.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Xgenomes Corp. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | September 25, 2024 |
| Project end | May 24, 2026 |
| Funding year | 2024 |
| Award (this year) | $384,418 |
| NIH project number | 1R43HG013911-01 |
| Project ID | NIH-11008187 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals undergoing genetic testing for conditions such as cancer or cystic fibrosis.
✕Less likely to help
Patients who do not require genetic testing or monitoring for genetic conditions may not benefit from this research.
What this research studies
This research focuses on creating an innovative DNA sequencing platform that improves upon current technologies. By using super-resolution fluorescence imaging, the method reads short segments of DNA sequences more efficiently, allowing for multiple readings of each nucleotide. Advanced algorithms will process the images and assemble the sequences, aiming to significantly enhance accuracy and reduce costs. This could lead to better monitoring of conditions like cancer and genetic disorders.
Why it matters
Potential benefit: If successful, this research could provide patients with more accurate and cost-effective DNA sequencing, improving disease monitoring and treatment options.
How similar studies have gone: Previous research has shown promise in using super-resolution imaging for DNA sequencing, indicating potential success for this novel approach.
Where this research is happening
-
Xgenomes Corp.
Cambridge, United States Active
Researchers
- Principal investigator: Mir, Kalim Ullah — Xgenomes Corp.
- Study coordinator: Mir, Kalim Ullah
Related research
Other NIH-funded projects on the same topics.
-
Analyzing DNA methylation to understand gene regulation and disease
This study is looking at how changes in DNA can affect health, especially for people with cancer or autoimmune diseases, and aims to develop better ways to detect these changes so that doctors can offer more accurate diagnoses and personalized treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.